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Der3p/Hrd1p Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Lumenal and Integral Membrane Proteins

We have studied components of the endoplasmic reticulum (ER) proofreading and degradation system in the yeast Saccharomyces cerevisiae. Using a der3–1 mutant defective in the degradation of a mutated lumenal protein, carboxypeptidase yscY (CPY*), a gene was cloned which encodes a 64-kDa protein of t...

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Bibliografiske detaljer
Main Authors: Bordallo, Javier, Plemper, Richard K., Finger, Andreas, Wolf, Dieter H.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25244/
https://ncbi.nlm.nih.gov/pubmed/9437001
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