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Uracil-Directed Ligand Tethering: An Efficient Strategy for Uracil DNA Glycosylase (UNG) Inhibitor Development
Uracil DNA glycosylase (UNG) is an important DNA repair enzyme that recognizes and excises uracil bases in DNA using an extrahelical recognition mechanism. It is emerging as a desirable target for small molecule inhibitors given its key role in a wide range of biological processes including the gene...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2522323/ https://ncbi.nlm.nih.gov/pubmed/16332091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja055846n |
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