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p53-Targeted LSD1 Functions in Repression of Chromatin Structure and Transcription In Vivo

Despite years of study focused on the tumor suppressor p53, little is understood about its functions in normal, differentiated cells. We found that p53 directly interacts with lysine-specific demethylase 1 (LSD1) to alter chromatin structure and confer developmental repression of the tumor marker al...

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Bibliografiske detaljer
Main Authors: Tsai, Wen-Wei, Nguyen, Thi T., Shi, Yang, Barton, Michelle Craig
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519740/
https://ncbi.nlm.nih.gov/pubmed/18573881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00287-08
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