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The DNA Helicase Activity of BLM Is Necessary for the Correction of the Genomic Instability of Bloom Syndrome Cells

Bloom syndrome (BS) is a rare autosomal recessive disorder characterized by growth deficiency, immunodeficiency, genomic instability, and the early development of cancers of many types. BLM, the protein encoded by BLM, the gene mutated in BS, is localized in nuclear foci and absent from BS cells. BL...

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Auteurs principaux: Neff, Norma F., Ellis, Nathan A., Ye, Tian Zhang, Noonan, James, Huang, Kelly, Sanz, Maureen, Proytcheva, Maria
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC25194/
https://ncbi.nlm.nih.gov/pubmed/10069810
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