Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes

We previously showed that the 12/15-lipoxygenase (12/15-LO) pathway of arachidonate acid metabolism is involved in multiple events related to diabetic nephropathy (DN), including glomerular hypertrophy and extracellular matrix deposition (Kang SW, Adler SG, Nast CC, LaPage J, Gu JL, Nadler JL, Natar...

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Main Authors: Yuan, Hang, Lanting, Linda, Xu, Zhong-Gao, Li, Shu-Lian, Swiderski, Piotr, Putta, Sumanth, Jonnalagadda, Mahesh, Kato, Mitsuo, Natarajan, Rama
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519183/
https://ncbi.nlm.nih.gov/pubmed/18562637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90268.2008
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