TGF-β Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy

MicroRNAs (miRNAs), such as miR-192, mediate the actions of transforming growth factor β1 (TGF-β) related to the pathogenesis of diabetic kidney diseases. We found that the biphasic induction of miR-192 expression by TGF-β in mouse renal glomerular mesangial cells initially involved the Smad transcr...

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Detalhes bibliográficos
Main Authors: Kato, Mitsuo, Dang, Varun, Wang, Mei, Park, Jung Tak, Deshpande, Supriya, Kadam, Swati, Mardiros, Armen, Zhan, Yumei, Oettgen, Peter, Putta, Sumanth, Yuan, Hang, Lanting, Linda, Natarajan, Rama
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723389/
https://ncbi.nlm.nih.gov/pubmed/23737551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003389
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