E2-25K/Hip-2 regulates caspase-12 in ER stress–mediated Aβ neurotoxicity

Amyloid-β (Aβ) neurotoxicity is believed to contribute to the pathogenesis of Alzheimer's disease (AD). Previously we found that E2-25K/Hip-2, an E2 ubiquitin-conjugating enzyme, mediates Aβ neurotoxicity. Here, we report that E2-25K/Hip-2 modulates caspase-12 activity via the ubiquitin/proteas...

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Detalhes bibliográficos
Main Authors: Song, Sungmin, Lee, Huikyong, Kam, Tae-In, Tai, Mei Ling, Lee, Joo-Yong, Noh, Jee-Yeon, Shim, Sang Mi, Seo, Soo Jung, Kong, Young-Yun, Nakagawa, Toshiyuki, Chung, Chul-Woong, Choi, Deog-Young, Oubrahim, Hammou, Jung, Yong-Keun
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518707/
https://ncbi.nlm.nih.gov/pubmed/18710920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711066
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