SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition

Accumulation of expanded polyglutamine proteins is considered to be a major pathogenic biomarker of Huntington disease. We isolated SCAMP5 as a novel regulator of cellular accumulation of expanded polyglutamine track protein using cell-based aggregation assays. Ectopic expression of SCAMP5 augments...

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Detalhes bibliográficos
Main Authors: Noh, Jee-Yeon, Lee, Huikyong, Song, Sungmin, Kim, Nam Soon, Im, Wooseok, Kim, Manho, Seo, Hyemyung, Chung, Chul-Woong, Chang, Jae-Woong, Ferrante, Robert J., Yoo, Young-Jun, Ryu, Hoon, Jung, Yong-Keun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670137/
https://ncbi.nlm.nih.gov/pubmed/19240033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807620200
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