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Site-Specific Incorporation of Allosteric-Inhibition Sites in a Protein Tyrosine Phosphatase
Small molecules that can be used to specifically control the activity of cellular gene products are key tools in chemical biology. Here, we present a scanning-insertional-mutagenesis approach to identify protein tyrosine phosphatase (PTP) mutants whose activities can be selectively modulated by a sm...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518263/ https://ncbi.nlm.nih.gov/pubmed/17346049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja069098t |
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