Gating Consequences of Charge Neutralization of Arginine Residues in the S(4) Segment of K(v)7.2, an Epilepsy-Linked K(+) Channel Subunit

The K(v)7.2 subunits are the main molecular determinants of the M-current, a widespread K(+) current regulating neuronal excitability. Mutations in the K(v)7.2 gene cause benign familial neonatal seizures, an autosomally inherited human epilepsy. The benign familial neonatal seizure-causing mutation...

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Main Authors: Miceli, Francesco, Soldovieri, Maria Virginia, Hernandez, Ciria C., Shapiro, Mark S., Annunziato, Lucio, Taglialatela, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2008
Assuntos:
Channels, Receptors, and Electrical Signaling
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517032/
https://ncbi.nlm.nih.gov/pubmed/18515377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.128371
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