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Gating Consequences of Charge Neutralization of Arginine Residues in the S(4) Segment of K(v)7.2, an Epilepsy-Linked K(+) Channel Subunit
The K(v)7.2 subunits are the main molecular determinants of the M-current, a widespread K(+) current regulating neuronal excitability. Mutations in the K(v)7.2 gene cause benign familial neonatal seizures, an autosomally inherited human epilepsy. The benign familial neonatal seizure-causing mutation...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Biophysical Society
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517032/ https://ncbi.nlm.nih.gov/pubmed/18515377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.128371 |
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