Atypical Gating Of M-Type Potassium Channels Conferred by Mutations in Uncharged Residues in the S(4) Region of KCNQ2 Causing Benign Familial Neonatal Convulsions

Heteromeric assembly of KCNQ2 and KCNQ3 subunits underlie the M-current (I(KM)), a slowly activating and noninactivating neuronal K(+) current. Mutations in KCNQ2 and KCNQ3 genes cause benign familial neonatal convulsions (BFNCs), a rare autosomal-dominant epilepsy of the newborn. In the present stu...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Soldovieri, Maria Virginia, Cilio, Maria Roberta, Miceli, Francesco, Bellini, Giulia, Miraglia del Giudice, Emanuele, Castaldo, Pasqualina, Hernandez, Ciria C., Shapiro, Mark S., Pascotto, Antonio, Annunziato, Lucio, Taglialatela, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672104/
https://ncbi.nlm.nih.gov/pubmed/17475800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0580-07.2007
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