The Spindle Checkpoint Functions of Mad3 and Mad2 Depend on a Mad3 KEN Box-mediated Interaction with Cdc20-Anaphase-promoting Complex (APC/C)

Mitotic progression is driven by proteolytic destruction of securin and cyclins. These proteins are labeled for destruction by an ubiquitin-protein isopeptide ligase (E3) known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C requires activators (Cdc20 or Cdh1) to efficiently recogn...

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Bibliografiske detaljer
Main Authors: Sczaniecka, Matylda, Feoktistova, Anna, May, Karen M., Chen, Jun-Song, Blyth, Julie, Gould, Kathleen L., Hardwick, Kevin G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Molecular Basis of Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516979/
https://ncbi.nlm.nih.gov/pubmed/18556659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803594200
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