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Mad3 KEN Boxes Mediate both Cdc20 and Mad3 Turnover, and Are Critical for the Spindle Checkpoint

Mitotic progression is controlled by proteolytic destruction of securin and cyclin. The mitotic E3 ubiquitin ligase, known as the anaphase promoting complex or cyclosome (APC/C), in partnership with its activators Cdc20p and Cdh1p, targets these proteins for degradation. In the presence of defective...

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Bibliografiske detaljer
Main Authors: King, Emma M.J., van der Sar, Sjaak J.A., Hardwick, Kevin G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829190/
https://ncbi.nlm.nih.gov/pubmed/17406666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000342
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