Biosynthesis of 2-Hydroxyethylphosphonate, an Unexpected Intermediate Common to Multiple Phosphonate Biosynthetic Pathways

Phosphonic acids encompass a common yet chemically diverse class of natural products that often possess potent biological activities. Here we report that, despite the significant structural differences among many of these compounds, their biosynthetic routes contain an unexpected common intermediate...

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Autores principales: Shao, Zengyi, Blodgett, Joshua A. V., Circello, Benjamin T., Eliot, Andrew C., Woodyer, Ryan, Li, Gongyong, van der Donk, Wilfred A., Metcalf, William W., Zhao, Huimin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516978/
https://ncbi.nlm.nih.gov/pubmed/18544530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801788200
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