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Dynamic energy landscape view of coupled binding and protein conformational change: Induced-fit versus population-shift mechanisms

Allostery, the coupling between ligand binding and protein conformational change, is the heart of biological network and it has often been explained by two representative models, the induced-fit and the population-shift models. Here, we clarified for what systems one model fits better than the other...

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Bibliografske podrobnosti
Main Authors: Okazaki, Kei-ichi, Takada, Shoji
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516237/
https://ncbi.nlm.nih.gov/pubmed/18678900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802524105
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