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An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin. Immunotoxin BL22 targets CD22 positive malignancies and is composed of an anti-CD22 Fv fused to a 38-kDa fragment of Pseudomonas exotoxin A (PE38). BL22 has produced many...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516223/ https://ncbi.nlm.nih.gov/pubmed/18678888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804851105 |
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