Natural BH3-mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

Anti-apoptotic members of the Bcl-2 family proteins are overexpressed in prostate cancer and are promising molecular targets for modulating chemoresistance of prostate cancer. (-)-Gossypol, a natural BH3-mimetic, is a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 currently in Phase II clinical tria...

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Bibliografische gegevens
Hoofdauteurs: Meng, Yang, Tang, Wenhua, Dai, Yao, Wu, Xiaoqing, Liu, Meilan, Ji, Qing, Ji, Min, Pienta, Kenneth, Lawrence, Theodore, Xu, Liang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515935/
https://ncbi.nlm.nih.gov/pubmed/18645028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0333
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