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TGFβ1, TNFα, and insulin signaling crosstalk in regulation of the rat cholesterol 7α-hydroxylase gene expression
The TGFβ1/Smad pathway plays a critical role in cholestasis and liver fibrosis. Previous studies show that TGFβ1, TNFα, and insulin inhibit cholesterol 7α-hydroxylase (CYP7A1) gene transcription and bile acid synthesis in human hepatocytes. In this study, we investigated insulin, TGFβ1, and TNFα reg...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515524/ https://ncbi.nlm.nih.gov/pubmed/18511845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800140-JLR200 |
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