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CTLA4 blockade expands FoxP3(+) regulatory and activated effector CD4(+) T cells in a dose-dependent fashion
Cytotoxic T lymphocyte–associated antigen 4 (CTLA4) delivers inhibitory signals to activated T cells. CTLA4 is constitutively expressed on regulatory CD4(+) T cells (Tregs), but its role in these cells remains unclear. CTLA4 blockade has been shown to induce antitumor immunity. In this study, we exa...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515138/ https://ncbi.nlm.nih.gov/pubmed/18523152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-125435 |
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