11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic processes, including hepatic gluconeogenesis. It recently has been recognized that intracellular glucocorticoid concentrations are determined not only by plasma hormone levels, but also by intracellular 11β-hydroxysteroid...

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Detalhes bibliográficos
Main Authors: Kotelevtsev, Yuri, Holmes, Megan C., Burchell, Ann, Houston, Pamela M., Schmoll, Dieter, Jamieson, Pauline, Best, Ruth, Brown, Roger, Edwards, Christopher R. W., Seckl, Jonathan R., Mullins, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC25139/
https://ncbi.nlm.nih.gov/pubmed/9405715
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