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Properties of a simian virus 40 mutant T antigen substituted in the hydrophobic region: defective ATPase and oligomerization activities and altered phosphorylation accompany an inability to complex with cellular p53.

We have analyzed the biochemical properties of a nonviable simian virus 40 (SV40) mutant encoding a large T antigen (T) bearing an amino acid substitution (Pro-584-Leu) in its hydrophobic region. Mutant 5080 has an altered cell type specificity for transformation (transforming mouse C3H10T1/2 but no...

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書誌詳細
主要な著者: Tack, L C, Cartwright, C A, Wright, J H, Eckhart, W, Peden, K W, Srinivasan, A, Pipas, J M
フォーマット: Artigo
言語:Inglês
出版事項: 1989
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC250910/
https://ncbi.nlm.nih.gov/pubmed/2545911
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