Properties of a simian virus 40 mutant T antigen substituted in the hydrophobic region: defective ATPase and oligomerization activities and altered phosphorylation accompany an inability to complex with cellular p53.

We have analyzed the biochemical properties of a nonviable simian virus 40 (SV40) mutant encoding a large T antigen (T) bearing an amino acid substitution (Pro-584-Leu) in its hydrophobic region. Mutant 5080 has an altered cell type specificity for transformation (transforming mouse C3H10T1/2 but no...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Tack, L C, Cartwright, C A, Wright, J H, Eckhart, W, Peden, K W, Srinivasan, A, Pipas, J M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250910/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2545911/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.8.3362-3367.1989
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