Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation.

We used a heteroduplex deletion loop mutagenesis procedure for directing sodium bisulfite-induced mutations to specific sites on viral or plasmid DNA to generate a series of SV40 large T-antigen point mutants. The mutations were directed to a region of the T-antigen gene, 0.5 map units, that is thou...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Peden, K W, Pipas, J M
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1985
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC254890/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2989548/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.55.1.1-9.1985
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