Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation.

We used a heteroduplex deletion loop mutagenesis procedure for directing sodium bisulfite-induced mutations to specific sites on viral or plasmid DNA to generate a series of SV40 large T-antigen point mutants. The mutations were directed to a region of the T-antigen gene, 0.5 map units, that is thou...

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Bibliografiska uppgifter
Huvudupphovsmän: Peden, K W, Pipas, J M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1985
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC254890/
https://ncbi.nlm.nih.gov/pubmed/2989548
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