Aphidicolin resistance in herpes simplex virus type 1 appears to alter substrate specificity in the DNA polymerase.

We describe novel mutants of herpes simplex virus which are resistant to aphidicolin. Their mutant phenotypes suggest that they encode DNA polymerases with altered substrate recognition. This conclusion is based on their abnormal sensitivity to polymerase inhibitors and to the abnormal mutation rate...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Hall, J D, Woodward, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250806/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2542598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.6.2874-2876.1989
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