Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U.

The triphosphate form of the acyclovir analog BW759U (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) inhibited the DNA polymerases (EC 2.7.7.7) from several strains of herpes simplex virus type 1. Two acyclovir triphosphate-resistant DNA polymerases were as sensitive to BW759U-triphosphate as...

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Main Authors: St Clair, M H, Miller, W H, Miller, R L, Lambe, C U, Furman, P A
Formato: Artigo
Idioma:Inglês
Publicado em: 1984
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC185472/
https://ncbi.nlm.nih.gov/pubmed/6324666
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