Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U.

The triphosphate form of the acyclovir analog BW759U (9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine) inhibited the DNA polymerases (EC 2.7.7.7) from several strains of herpes simplex virus type 1. Two acyclovir triphosphate-resistant DNA polymerases were as sensitive to BW759U-triphosphate as...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	St Clair, M H, Miller, W H, Miller, R L, Lambe, C U, Furman, P A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185472/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6324666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.25.2.191
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