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ZEB1 Links Epithelial-Mesenchymal Transition and Cellular Senescence

Overexpression of zinc finger E-box binding homeobox transcription factor 1 (ZEB1) in cancer leads to epithelial-to-mesenchymal transition (EMT) and increased metastasis. As opposed to overexpression, we show that mutation of the ZEB1 gene in mice causes a mesenchymal-epithelial transition in gene e...

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Main Authors: Liu, Yongqing, El-Naggar, Shahenda, Darling, Douglas S., Higashi, Yujiro, Dean, Douglas C.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2507753/
https://ncbi.nlm.nih.gov/pubmed/18192284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.007047
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