ZEB1 drives epithelial-to-mesenchymal transition in lung cancer

Increased expression of zinc finger E-box binding homeobox 1 (ZEB1) is associated with tumor grade and metastasis in lung cancer, likely due to its role as a transcription factor in epithelial-to-mesenchymal transition (EMT). Here, we modeled malignant transformation in human bronchial epithelial ce...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Larsen, Jill E., Nathan, Vaishnavi, Osborne, Jihan K., Farrow, Rebecca K., Deb, Dhruba, Sullivan, James P., Dospoy, Patrick D., Augustyn, Alexander, Hight, Suzie K., Sato, Mitsuo, Girard, Luc, Behrens, Carmen, Wistuba, Ignacio I., Gazdar, Adi F., Hayward, Nicholas K., Minna, John D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004933/
https://ncbi.nlm.nih.gov/pubmed/27500490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76725
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