Mutant varicella-zoster virus thymidine kinase: correlation of clinical resistance and enzyme impairment.
Varicella-zoster virus (VZV) encodes a thymidine kinase (EC 2.7.2.21) which phosphorylates several antiviral nucleoside analogs, including acyclovir (ACV). A mutation in the VZV thymidine kinase coding sequence, resulting in an arginine-to-glutamine substitution at amino acid residue 130 (R130Q), is...
Guardat en:
| Publicat a: | J Virol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1991
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250677/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.12.6407-6413.1991 |
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