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Mutant varicella-zoster virus thymidine kinase: correlation of clinical resistance and enzyme impairment.

Varicella-zoster virus (VZV) encodes a thymidine kinase (EC 2.7.2.21) which phosphorylates several antiviral nucleoside analogs, including acyclovir (ACV). A mutation in the VZV thymidine kinase coding sequence, resulting in an arginine-to-glutamine substitution at amino acid residue 130 (R130Q), is...

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Udgivet i:J Virol
Principais autores: Roberts, G B, Fyfe, J A, Gaillard, R K, Short, S A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250677/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658351/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.12.6407-6413.1991
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