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Foxp3 Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

Addition of rapamycin to cultures of expanding natural CD4(+)CD25(+)Foxp3(+) T regulatory cells (Tregs) helps maintain their suppressive activity, but the underlying mechanism is unclear. Pim 2 is a serine/threonine kinase that can confer rapamycin resistance. Unexpectedly, pim 2 was found to be con...

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Detalhes bibliográficos
Main Authors: Basu, Samik, Golovina, Tatiana, Mikheeva, Tatiana, June, Carl H., Riley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504517/
https://ncbi.nlm.nih.gov/pubmed/18424697
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