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Foxp3 Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin
Addition of rapamycin to cultures of expanding natural CD4(+)CD25(+)Foxp3(+) T regulatory cells (Tregs) helps maintain their suppressive activity, but the underlying mechanism is unclear. Pim 2 is a serine/threonine kinase that can confer rapamycin resistance. Unexpectedly, pim 2 was found to be con...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504517/ https://ncbi.nlm.nih.gov/pubmed/18424697 |
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