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In vitro selection of small RNA-cleaving deoxyribozymes that cleave pyrimidine–pyrimidine junctions

Herein, we sought new or improved endoribonucleases based on catalytic DNA molecules known as deoxyribozymes. The current repertoire of RNA-cleaving deoxyribozymes can cleave nearly all of the 16 possible dinucleotide junctions with rates of at least 0.1/min, with the exception of pyrimidine–pyrimid...

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Hlavní autoři: Schlosser, Kenny, Gu, Jimmy, Lam, Jeffrey C. F., Li, Yingfu
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504313/
https://ncbi.nlm.nih.gov/pubmed/18644842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn396
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