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A genotype-to-phenotype map of in vitro selected RNA-cleaving DNAzymes: implications for accessing the target phenotype

Herein, we describe a case study into the population dynamics of in vitro selection, using RNA-cleaving DNAzymes as a model system. We sought to understand how the composition of the population can change over time in response to different levels of selection pressure, and how well these changes are...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Schlosser, Kenny, Lam, Jeffrey C. F., Li, Yingfu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2009
Aiheet:
RNA
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699508/
https://ncbi.nlm.nih.gov/pubmed/19357090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp222
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