Ku80 removal from DNA through double strand break–induced ubiquitylation

The Ku70/Ku80 heterodimer, or Ku, is the central component of the nonhomologous end joining (NHEJ) pathway of double strand break (DSB) repair. Because Ku forms a ring through which the DSB threads, it likely becomes topologically attached to DNA during repair. The mechanism for its removal was unkn...

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Autors principals: Postow, Lisa, Ghenoiu, Cristina, Woo, Eileen M., Krutchinsky, Andrew N., Chait, Brian T., Funabiki, Hironori
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2500133/
https://ncbi.nlm.nih.gov/pubmed/18678709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200802146
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