Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

In mammals, two homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2), sense cytosolic iron levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1 (TfR1...

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Detalhes bibliográficos
Main Authors: Ghosh, Manik C., Tong, Wing-Hang, Zhang, Deliang, Ollivierre-Wilson, Hayden, Singh, Anamika, Krishna, Murali C., Mitchell, James B., Rouault, Tracey A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2497459/
https://ncbi.nlm.nih.gov/pubmed/18685102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805361105
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