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Heme Degradation and Oxidative Stress in Murine Models for Hemoglobinopathies: Thalassemia, Sickle Cell Disease and Hemoglobin C Disease

Red blood cells with abnormal hemoglobins (Hb) are frequently associated with increased hemoglobin autoxidation, accumulation of iron in membranes, increased membrane damage and a shorter red cell life span. The mechanisms for many of these changes have not been elucidated. We have shown in our prev...

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Detalhes bibliográficos
Main Authors: Nagababu, Enika, Fabry, Mary E., Nagel, Ronald L., Rifkind, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2497002/
https://ncbi.nlm.nih.gov/pubmed/18262448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2007.12.003
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