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Stereoselectivity of Intramolecular S(N)′ Cyclizations of Alkyllithium Reagents on Methoxy Alkenes

The cyclization of alkyllithium reagents onto methoxy alkenes has been investigated. The alkyllithium reagent was generated by reductive lithiation of an alkyl nitrile. In an unbiased substrate, a methoxy leaving group attached to a stereogenic secondary carbon atom led to the cyclization product wi...

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Autori principali: La Cruz, Thomas E., Rychnovsky, Scott D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2496923/
https://ncbi.nlm.nih.gov/pubmed/16438522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo052166u
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