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Synthesis of the C1-C52 Fragment of Amphidinol 3, Featuring a β-Alkoxy Alkyllithium Addition Reaction

An advanced intermediate for the synthesis of amphidinol 3 has been prepared. A cross-metathesis reaction was used to couple the C1-C12 and C13-C26 segments. An unusual β-alkoxy alkyllithium reagent was generated from this segment and added to a Weinreb amide to assemble the C1-C52 section of amphid...

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Detalhes bibliográficos
Main Authors: Huckins, John R., de Vicente, Javier, Rychnovsky, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2496920/
https://ncbi.nlm.nih.gov/pubmed/17944478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol7020934
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