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Stereocontrolled Synthesis of Vicinally Functionalized Piperidines by Nucleophilic β-Addition of Alkyllithiums to α-Aryl Substituted Piperidine Enecarbamates

Substituted piperidines are emerging as important medicinally-active structural motifs. Here, we report highly stereoselective carbolithiation reactions of α-aryl piperidine enecarbamates that offer direct access to vicinally-substituted piperidine compounds. We have also demonstrated that the carba...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Beng, Timothy K., Takeuchi, Hironori, Weber, Manuel, Sarpong, Richmond
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435544/
https://ncbi.nlm.nih.gov/pubmed/25845938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc01307k
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