Protein Kinase A (PKA) Isoform RII(β) Mediates the Synergistic Killing Effect of cAMP and Glucocorticoid in Acute Lymphoblastic Leukemia Cells

Protein kinase A (PKA) or cAMP-dependent protein kinase (cAPK) mediates the synergistic effects of cAMP- and glucocorticoid (GC)-induced apoptosis in lymphoid cells. Using two human acute lymphoblastic leukemia cell (CEM) clones with respective GC-sensitive and GC-resistant phenotypes, we discovered...

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Autors principals: Ji, Zhenyu, Mei, Fang C., Miller, Aaron L., Thompson, E. Brad, Cheng, Xiaodong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494930/
https://ncbi.nlm.nih.gov/pubmed/18544528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803193200
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