Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

Thymidine analogue-associated mutations (TAMs) in reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) cause resistance to 3′-azido-3′-deoxythymidine (AZT) through excision of the incorporated monophosphate. Mutations in the connection domain of HIV-1 RT can augment AZT resi...

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Bibliographic Details
Main Authors: Ehteshami, Maryam, Beilhartz, Greg L., Scarth, Brian J., Tchesnokov, Egor P., McCormick, Suzanne, Wynhoven, Brian, Harrigan, P. Richard, Götte, Matthias
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494928/
https://ncbi.nlm.nih.gov/pubmed/18547911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803521200
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