Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

The thymidine analog 3'-azido-3'-deoxythymidine (BW A509U, azidothymidine) can inhibit human immunodeficiency virus (HIV) replication effectively in the 50-500 nM range [Mitsuya, H., Weinhold, K. J., Furman, P. A., St. Clair, M. H., Nusinoff-Lehrman, S., Gallo, R. C., Bolognesi, D., Barry,...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Furman, P A, Fyfe, J A, St Clair, M H, Weinhold, K, Rideout, J L, Freeman, G A, Lehrman, S N, Bolognesi, D P, Broder, S, Mitsuya, H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC386922/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2430286/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.21.8333
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