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Cystic Fibrosis Transmembrane Regulator Missing the First Four Transmembrane Segments Increases Wild Type and ΔF508 Processing

We previously generated an adenoassociated viral gene therapy vector, rAAV-Δ264 cystic fibrosis transmembrane conductance regulator (CFTR), missing the first four transmembrane domains of CFTR. When infected into monkey lungs, Δ264 CFTR increased the levels of endogenous wild type CFTR protein. To u...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Cebotaru, Liudmila, Vij, Neeraj, Ciobanu, Igor, Wright, Jerry, Flotte, Terence, Guggino, William B.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494918/
https://ncbi.nlm.nih.gov/pubmed/18508776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709156200
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