Cystic Fibrosis Transmembrane Regulator Missing the First Four Transmembrane Segments Increases Wild Type and ΔF508 Processing

We previously generated an adenoassociated viral gene therapy vector, rAAV-Δ264 cystic fibrosis transmembrane conductance regulator (CFTR), missing the first four transmembrane domains of CFTR. When infected into monkey lungs, Δ264 CFTR increased the levels of endogenous wild type CFTR protein. To u...

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Detalhes bibliográficos
Main Authors: Cebotaru, Liudmila, Vij, Neeraj, Ciobanu, Igor, Wright, Jerry, Flotte, Terence, Guggino, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494918/
https://ncbi.nlm.nih.gov/pubmed/18508776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709156200
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