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Cystic Fibrosis Transmembrane Regulator Missing the First Four Transmembrane Segments Increases Wild Type and ΔF508 Processing

We previously generated an adenoassociated viral gene therapy vector, rAAV-Δ264 cystic fibrosis transmembrane conductance regulator (CFTR), missing the first four transmembrane domains of CFTR. When infected into monkey lungs, Δ264 CFTR increased the levels of endogenous wild type CFTR protein. To u...

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Main Authors: Cebotaru, Liudmila, Vij, Neeraj, Ciobanu, Igor, Wright, Jerry, Flotte, Terence, Guggino, William B.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494918/
https://ncbi.nlm.nih.gov/pubmed/18508776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709156200
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