Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate the host response to infection. Two such proteins, B14 and A52, act inside infected cells to inhibit activation of NF-κB, thereby blocking the production of pro-inflammatory cytokines. We have solved the crystal s...

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Detalhes bibliográficos
Main Authors: Graham, Stephen C., Bahar, Mohammad W., Cooray, Samantha, Chen, Ron A.-J., Whalen, Daniel M., Abrescia, Nicola G. A., Alderton, David, Owens, Raymond J., Stuart, David I., Smith, Geoffrey L., Grimes, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494871/
https://ncbi.nlm.nih.gov/pubmed/18704168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000128
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