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Design, synthesis and evaluation of inhibitors of cathepsin L: exploiting a unique thiocarbazate chemotype
Recently, we identified a thiocarbazate that exhibits potent inhibitory activity against human cathepsin L. Since this structure represents a novel chemotype with potential for activity against the entire cysteine protease family, we designed, synthesized and assayed a series of analogs to probe the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2494853/ https://ncbi.nlm.nih.gov/pubmed/18499453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.04.065 |
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