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Design, synthesis and evaluation of inhibitors of cathepsin L: exploiting a unique thiocarbazate chemotype

Recently, we identified a thiocarbazate that exhibits potent inhibitory activity against human cathepsin L. Since this structure represents a novel chemotype with potential for activity against the entire cysteine protease family, we designed, synthesized and assayed a series of analogs to probe the...

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Main Authors: Myers, Michael C., Shah, Parag P., Beavers, Mary Pat, Napper, Andrew D., Diamond, Scott L., Smith, Amos B., Huryn, Donna M.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494853/
https://ncbi.nlm.nih.gov/pubmed/18499453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.04.065
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