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KINETIC CHARACTERIZATION AND MOLECULAR DOCKING OF A NOVEL, POTENT, AND SELECTIVE SLOW-BINDING INHIBITOR OF HUMAN CATHEPSIN L

A novel small molecule thiocarbazate (PubChem SID 26681509), a potent inhibitor of human cathepsin L (EC 3.4.22.15) with an IC(50) of 56 nM, was developed following a 57,821 compound screen of the NIH Molecular Libraries Small Molecule Repository. After a 4 hr preincubation with cathepsin L, this co...

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書誌詳細
主要な著者: Shah, Parag P., Myers, Michael C., Beavers, Mary Pat, Purvis, Jeremy E., Jing, Huiyan, Grieser, Heather J., Sharlow, Elizabeth R., Napper, Andrew D., Huryn, Donna M., Cooperman, Barry S., Smith, Amos B., Diamond, Scott L.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575030/
https://ncbi.nlm.nih.gov/pubmed/18403718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.046219
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