Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.

The poliovirus polyprotein is cotranslationally linked to myristic acid at its amino-terminal glycine residue. We investigated the role of myristoylation in the viral replication cycle by site-directed mutagenesis of this glycine codon. Synthetic full-length RNA transcripts carrying a Gly-to-Ala mut...

Полное описание

Библиографические подробности

Опубликовано в::	J Virol
Главные авторы:	Kräusslich, H G, Hölscher, C, Reuer, Q, Harber, J, Wimmer, E
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1990
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2157900/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.5.2433-2436.1990
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