Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.

The poliovirus polyprotein is cotranslationally linked to myristic acid at its amino-terminal glycine residue. We investigated the role of myristoylation in the viral replication cycle by site-directed mutagenesis of this glycine codon. Synthetic full-length RNA transcripts carrying a Gly-to-Ala mut...

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Bibliographic Details
Main Authors: Kräusslich, H G, Hölscher, C, Reuer, Q, Harber, J, Wimmer, E
Format: Artigo
Language:Inglês
Published: 1990
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC249411/
https://ncbi.nlm.nih.gov/pubmed/2157900
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